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Hormonal Headaches: The Estrogen, Histamine & Cytokine Connection

Hormonal Headaches: The Estrogen, Histamine & Cytokine Connection

Cyclical Headaches in Ovulation and Late Luteal Phase

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arc.woman
Jul 16, 2025
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Hormonal Headaches: The Estrogen, Histamine & Cytokine Connection
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Ever notice you get a massive headache at certain times in your cycle, like mid-month or right before your period? You’re not imagining it; it could be your hormones playing up. Many women in their 20s and 30s find that ovulation (around the middle of the cycle) and the late luteal phase (just before the period) bring on head-pounding migraines or “peri…

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